Even though in bodybuilding circles we don’t hear much about Sermorelin, this doesn’t mean that this peptide does not have its uses. In fact, anti-aging and hormone replacement clinics have been prescribing it for years because it works as a clean GHRH. The problem for the bodybuilder or athlete is that it has a very short half-life of about ten (10) minutes. This becomes an unattractive feature when compared to the half-life of MOD GRF (1-29) (CJC 1295 without DAC), which comes in around 30 minutes. Despite its short window, it does bind quite effectively to the pituitary receptors. The other main down side associated with its very short half life is that it is quickly broken down by blood enzymes within minutes. This is why a GHRH peptide with a half life of 30 minutes or longer is desirable, since it will survive the blood enzyme death and allow it to circulate the body looking for hormone receptors to bind to.
