Detail:

        Estazolam (desmethylalprazolam, marketed under the brand names ProSom, Eurodin, Nuctalon) is a benzodiazepine derivative drug developed by Upjohn in the 1970s. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Estazolam is an intermediate-acting oral benzodiazepine.

        It is commonly prescribed for short-term treatment of insomnia.

Indications:

        Estazolam is prescribed for the short-term treatment of certain sleep disorders. It is an effective hypnotic drug showing efficacy in increasing the time spent asleep as well as reducing awakenings during the night. Combination with non-pharmacological options for sleep management results in long-term improvements in sleep quality after discontinuation of short-term estazolam therapy.Estazolam is also sometimes used as a preoperative sleep aid. It was found to be superior to triazolam in side effect profile in preoperative patients in a trial. Estazolam also has anxiolytic properties and due to its long half life can be an effective short-term treatment for insomnia associated with anxiety.

Side effects:

        A hang-over effect commonly occurs with next day impairments of mental and physical performance. Other side effects of estazolam include somnolence, dizziness, hypokinesia, and abnormal coordination.

Tolerance and dependence:

        The main safety concern of benzodiazepines such as estazolam is a benzodiazepine dependence and the subsequent benzodiazepine withdrawal syndrome which can occur upon discontinuation of the estazolam. A review of the literature found that long-term use of benzodiazepines such as estazolam is associated with drug tolerance, drug dependence, rebound insomnia and CNS related adverse effects. Estazolam should only be used short term and at the lowest effective dose to avoid complications related to long-term use. Non-pharmacological treatment options however, were found to have sustained improvements in sleep quality. The short-term benefits of benzodiazepines on sleep begin to reduce after a few days due to tolerance to the hypnotic effects of benzodiazepines in the elderly.

Contraindications and special caution:

        Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders.

Pharmacology:

        Estazolam is classed as a "triazolo" benzodiazepine drug. Estazolam exerts its therapeutic effects via its benzodiazepines receptor agonist properties. Estazolam at high doses decreases histamine turnover via its action at the benzodiazepine-GABA receptor complex in mouse brains.

Pharmacokinetics:

        Peak plasma levels are achieved within 1–6 hours. Estazolam is an intermediate acting benzodiazepine. The elimination half life of estazolam is an average of 19 hours, with a range of 8–31 hours. The major metabolite of estazolam is 4-hydroxyestazolam.

        We can provide Hallucinogens;Serotonin receptor modulators;Ergolines;Amphetamine;Anorectics;Decongestants;Monoamine releasing agents;Phenethylamines;Anxiolytics;Benzodiazepines;GABAA receptor positive modulators;Recreational drug;Club drugs;Euphoriants;Opioid receptor modulators；Analgesics；Stimulants;Monoamine neurotoxins;Serotonin receptor modulators;Sigma receptor modulators;Anticonvulsants;Antidotes;Glycine receptor modulators;Toxins;Globular proteins;chemical warfare and other chemical reagent .

       You can send message to us if you not see what you want product in our Web ,we will provide synthetic services for you.The synthesis time usually need 1-5 days.Wishing you a happy shopping.

Warm prompt:Please use it for chemical experiment,We are not liable for any legal liability.