Detail:

        Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. Products labeled as bath salts containing MDPV were previously sold as recreational drugs in gas stations and convenience stores in the United States, similar to the marketing for Spice and K2 as incense.

Appearance:

        The hydrochloride salt exists as a very fine, hygroscopic, crystalline powder that tends to clump to itself, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyrrolidine or alpha-dibrominated alkylphenones from either excess pyrrolidine or incomplete amination, respectively, during synthesis. These impurities likely account for its discoloration and fishy (pyrrolidine) or bromine-like odor, which worsens upon exposure to air, moisture, or bases.

Pharmacology:

        Methylenedioxypyrovalerone has no record of FDA approved medical use. MDPV has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already been provisionally established by a number of documented cases of misuse and addiction in humans, before the animal tests had been carried out.

        MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound pyrovalerone, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence.

        Other drugs with a similar chemical structure include α-pyrrolidinopropiophenone (α-PPP), 4'-methyl-α-pyrrolidinopropiophenone (M-α-PPP), 3',4'-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) and 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP).

Effects:

        MDPV acts as a stimulant and has been reported to produce effects similar to those of cocaine, methylphenidate, and amphetamines.

        The primary psychological effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. It has also been repeatedly noted for inducing irresistible cravings to re-administer.

        Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg.

Long term effects:

        Although there is no experience about the long-term effects of MDPV in humans, its has been reported that mice treated with MDPV during adolescence show reinforcing behavior patterns to cocaine which are higher than the control group. Also, these behavioural changes are related to alterations of factor expression directly related to addiction. All this suggests an increased vulnerability to cocaine abuse

        We can provide Hallucinogens;Serotonin receptor modulators;Ergolines;Amphetamine;Anorectics;Decongestants;Monoamine releasing agents;Phenethylamines;Anxiolytics;Benzodiazepines;GABAA receptor positive modulators;Recreational drug;Club drugs;Euphoriants;Opioid receptor modulators；Analgesics；Stimulants;Monoamine neurotoxins;Serotonin receptor modulators;Sigma receptor modulators;Anticonvulsants;Antidotes;Glycine receptor modulators;Toxins;Globular proteins;chemical warfare and other chemical reagent .

       You can send message to us if you not see what you want product in our Web ,we will provide synthetic services for you.The synthesis time usually need 1-5 days.Wishing you a happy shopping.

Warm prompt:Please use it for chemical experiment,We are not liable for any legal liability.