Liraglutide Side Chain

Pal-Glu(OSu)-OtBu


Product Name:Liraglutide Side Chain


Abbrevition:Pal-Glu(OSu)-OtBu


CAS No.:204521-63-1


Purity: ≥98%


Package Size: 1g/bottle、10g/bottle、100g/bottle


Storage: Store at -20±5℃, keep dry.



Liraglutide Side Chain


Liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist. Liraglutide is 97% homologous to native human GLP-1 by substituting arginine for lysine at position 341. Liraglutide is made by attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer on the remaining lysine residue at position 26 of the peptide precursor. Liraglutide was granted FDA approval to Novo Nordisk on Januray 25, 2010 as commericial name ”Victoza”.


SINOPEG is pleased to offer this C-16 fatty acid for your R&D and clinic research.

Reference:

1.Malm-Erjefalt M, etc: Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos. 2010 Nov;38(11):1944-53. doi: 10.1124/dmd.110.034066;


2.Knudsen B, etc: The Discovery and Development of Liraglutide and Semaglutide Frontiers in Endocrinology;


3.  Russell-Jones D: Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue. Mol Cell Endocrinol. 2009 Jan 15;297(1-2):137-40;


4.  FDA Drug Approval Package: Liraglutide; 


5.  FDA News Release: Liraglutide Indication 


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