MK-677 (Ibutamoren) Growth Hormone CAS:159634-47-6

MK-677 is a long-acting, potent, non-peptidic and selective antagonist of the growth hormone, secretagogue receptor





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Name:MK-677 (Ibutamoren)

CAS :159634-47-6

Formula:C27H36N4O5S

Molar mass:528.662 g/mol g·mol−1

Assay :  ≥98.0% (HPLC)

Form :  powder

Color :  white to beige





MK-677



Background:

MK-677 is the developmental code for the substance known as Ibutamoren. From what is known from research, MK-677 is a long-acting, potent, non-peptidic and selective antagonist of the growth hormone, secretagogue receptor (also known as ghrelin receptor). In other words, it helps in building muscle mass. However, what makes MK-677 unique is it does not increase cortisol levels (also known as the stress hormone) unlike most muscle-building growth hormones out there.

How it Works:

MK-677 is a bio-available and an orally active substance. Explaining how it works on a cellular level can be confusing but MK-677 actually works by targeting multiple regions of the brain that are responsible for metabolic engagement. It does this in 4 ways. It first increases production of GHRH which is a hormone that enhances growth. Secondly, works by reducing somatostatin, a hormone that helps to reduce GH release. Thirdly MK-677 works by promoting GHRH signals in your pituitary gland and lastly, it restrains somatostatin receptor signals. A daily dose of 5mg of MK-677 results in a significant increase in growth hormone levels.

How is it Administered:

The clinically tested approach of MK-677 is via oral administration.  The dosage may range from 5mg-25mg per day depending on factors such as weight and age. The great thing about MK-677 is it’s activated the moment it sits in the mouth. It’s best to take the MK-677 during early mornings on an empty stomach. MK-677 may interfere with sleep which is why it’s not recommended to be taken during night time.





Advantages of using MK-677:

Helps Build Muscle Mass – MK-677 increases IGF-1 and growth hormone levels, which then leads to a reduction of body fat, increasing muscle strength and increasing muscle mass.

Increases Bone Density – MK-677 capsules stimulate the increase of bone turnover. While it is true that bone density may decrease initially because of the increased bone turnover, but in the long run, it will make the bones stronger after the initial effects are over.

Potential MK-677 Side Effects:

MK-677 doesn’t have many reported side effects. Some users have reported water retention and a bloated feeling.


This is not a big issue and can be fought by lowering sodium intake. This is only a small price to pay for some great effects.









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