α-Pyrrolidinohexiophenone (α-PHP, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s which has been reported as a novel designer drug. It is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain, and is a structural isomer of pyrovalerone.

Adverse effects：

 α-PHP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PHP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs. α-PHP has also been linked to at least one death with pulmonary edema and moderately advanced atherosclerotic coronary disease when it was combined with pentedrone.

Pharmacology：

α-PHP acts as a norepinephrine-dopamine reuptake inhibitor with IC50 values of 14.2 and 12.8 nM, respectively, similar to its methylenedioxy derivative MDPV. Similar to other cathinones, α-PHP has been shown to have reinforcing effects in rats.

Chemistry：

α-PHP gives no reaction with the marquis reagent. It gives a grey/black reaction with the mecke reagent.

Detection in body fluids：

α-PHP may be quantified in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma α-PHP concentrations are expected to be in a range of 10–50 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients and >300 μg/L in victims of acute overdosage.